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Scientific Presentations

2022

Ng AY, Dantam J, Woods J, McEwen B, Jones L.. Examining Symptomatic Relief and Kinetic Tear Film Stability of I-DROP MGD Eye Drops Optometry's Meeting ePosters Virtual Event, Jun 8, 2022 [ Show Abstract ]

Background:
I-DROP MGD is a novel formulation of viscoadaptive hyaluronan, phosphorylcholine and glycerin to support integration, stabilization and enhancement of the tear film lipid layer as well as hydration of the ocular surface. The purpose of this study was to compare the difference in tear film measures after instilling I-DROP MGD (test) compared with another hyaluronic acid-based lubricant, Thealoz Duo (control), and to examine the subjective relief of dry eye symptoms with I-DROP MGD over 1-week.

Methods:
This prospective pilot study (n=10) comprised of two parts. Part 1 was a non-dispensing, doublemasked study involving contralateral application of test and control drops, followed by a two-hour observation period. Non-invasive tear break-up time (NITBUT), tear meniscus height (TMH) and lipid layer thickness (LLT) were measured out to 2 hours. Part 2 was a dispensing study, where one bottle of I-DROP MGD was provided to participants to use bilaterally at least once daily for 7 days. After 7 days, subjective ratings (0-100 scale) of comfort, soothing and quality of vision along with OSDI and SPEED scores were collected and compared with participant's habitual eye drops.

Results:
Part 1: NITBUT and TMH were significantly greater with I-DROP MGD (14.2 ± 5.1s and 0.42 ± 0.22mm) compared to Thealoz Duo (10.5 ± 5.7s and 0.29 ± 0.10mm) after 60 minutes (p =0.037) and 5-minutes of instillation (p =0.022) respectively; LLT was significantly thicker with Thealoz Duo (79.5 ± 15.7nm) compared to I-DROP MGD (68.5 ± 13.8nm) after 5 minutes of instillation (p=0.005). Part 2: Subjective ratings for comfort and soothing were significantly greater with I-DROP MGD (81.6 ± 5.7 and 86.8 ± 8.1) compared to habitual eye drops (73.3 ± 13.7 and 75.3 ± 19.8), p=0.027 and p=0.010 respectively. No significant differences were observed for quality of vision. OSDI and SPEED scores were significantly lower following use of I-DROP MGD (33.2 ± 11.7 and 11.1 ± 3.6) when compared to habitual drops (45.2 ± 14.7 and 14.9 ± 2.7), p=0.017 and p=0.006 respectively.

Conclusion:
When used for 7 days, I-DROP MGD resulted in clinically relevant reductions in dry eye symptoms, measured with OSDI.

2020

Craig J, Bitton E, Dantam J, Ngo W, Jones L. Subjective ocular awareness with the use of eyelid cleansing products available for the management of demodex folliculorum Academy at Home, 2020

2017

Dantam J, McCanna D, Subbaraman L, Jones L. Pro-inflammatory cytokine expression in human corneal epithelial cells after exposure to LPS derived from Pseudomonas aeruginosa Optom Vis Sci 2017;94: E-Abstract 174082

Dantam J, Subbaraman L, Jones L. Adhesion of emerging pathogens to contact lenses under the influence of an artificial tear solution Invest Ophthalmol Vis Sci 2017;E-Abstract 3079

2015

Dantam J, Heynen M, Coles-Brennan C, Fadli Z, Subbaraman L.  Kinetics of lysozyme sorption by various contact lens materials over short time periods BCLA Clinical Conference and Exhibition, 2015 [ PDF ]

Dantam J, Heynen M, Dominici C, Subbaraman L, Coles-Brennan C, Fadli Z, Jones L. Qualitative asymmetric mapping of lysozyme deposited on various contact lens materials using confocal laser scanning microscopy Invest Ophthalmol Vis Sci 2015;56: E-abstract 6091 [ PDF ]

2014

Jones L, Dantam J, McCanna D, Subbaraman L, Morgan P, Nichols J, Lakkis C. Impact of different contact lens care solutions and lens materials on contact lens storage case contamination BCLA Clinical Conference and Exhibition, 2014 [ PDF ]

Professional Publications

2019

Walsh K, Dantam J, Luensmann D. Contact Lens Wear and Its Disruption of the Tear Film Review of Cornea & Contact Lens 2019;May/June: 38-42.