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The IACLE Contact Lens Course IACLE. 2009.

Scleral lenses in special cases 2022.

Abdi,B., Mofidfar,M., Hassanpout,F., Cilingir,E. K., Kalajahi,S., Milani,P. K., Ghanbarzadeh,M., Fadel,D., Barnett,M., Ta,C. N., Leblanc,R. M., Chauhan,A., Abbasi,F. Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: Advances in extended and targeted drug delivery International Journal of Pharmaceutics 2023;638(May):122740 [ Show Abstract ]

The eye is one of the most important organs in the human body providing critical information on the environment. Many corneal diseases can lead to vision loss affecting the lives of people around the world. Ophthalmic drug delivery has always been a major challenge in the medical sciences. Since traditional methods are less efficient (∼5%) at delivering drugs to ocular tissues, contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. The main techniques used to achieve sustained release are discussed in this review, including soaking in drug solutions, incorporating drug into multilayered contact lenses, use of vitamin E barriers, molecular imprinting, nanoparticles, micelles and liposomes. The most clinically relevant results on different eye pathologies are presented. In addition, this review summarizes the benefits of contact lenses over eye drops, strategies for incorporating drugs into lenses to achieve sustained release, results of in vitro and in vivo studies, and recent advances in the commercialization of therapeutic contact lenses for allergic conjunctivitis.

Akbari,E., Imani,R., Shokrollahi,P., Keshel,S. H. Corneal sustained delivery of hyaluronic acid from nanofiber-containing ring-implanted contact lens Journal of Biomaterials Application 2023;37(6):992-1006 [ Show Abstract ]

Dry eye syndrome, as a persist corneal epithelial defect (PED), is an inconvenient ocular disorder that is generally treated by high-dosage, conventional eye drops. Addressing low efficacy and rather restricted bioavailability of the conventional eye drops, drug-eluting contact lenses (CLs) are widely used as alternatives in ophthalmic drug delivery applications. In the present study, a nanofiber-containing ring implant poly (vinyl alcohol) (PVA) hydrogel is designed as a carrier for hyaluronic acid (HA) delivery. hyaluronic acid is physically encapsulated in a nanofiber-containing ring-shaped hydrogel with a 2 mm width that is implanted in the final CLs hydrogel. The designed CL has 59% porosity, 275% swelling ratio and undergoes no weight loss at physiological conditions in14 days. In-vitro release studies were performed on the CLs with and without nanofibers. The results showed that nanofiber incorporation in the designed CL was highly influential in decreasing burst release and supported sustained release of HA over 14 days. In addition, nanofiber incorporation in the designed system strengthened the lens, and the young modulus of the PVA hydrogel increased from 6 to 10 kPa. Cell viability study also revealed no cell cytotoxicity and cell attachment. Overall, the study demonstrated the effective role of nanofibers in the physical strengthening of the CL. Also, the designed system holds promise as a potential candidate for HA delivery over an extended period for treating dry eye syndrome.

Alexander C, Jones L, Moody K. Evidence-based contact lens prescribing decisions Covalent Careers webinar, USA, November, 2020

Alexander C, Jones L, Moody K. Evidence-based contact lens prescribing decisions Johnson & Johnson Vision webinar, USA, September, 2020

Anderson T, Moezzi A, Varikooty J, Jones L, Woods C, Fonn D. A novel method for measuring contact lens movement and centration using a high speed camera and computer vision Optom Vis Sci 2011;88:E-abstract 115439

Averbeck K, Jones D, Westall C. A comparison of two logmar-based crowded visual acuity tests for the assessment of vision in children American Academy of Optometry, Orlando, 2000

Babaei Omali N, Subbaraman L, Coles-Brennan, Fadli Z, Jones L. Selective uptake of lysozyme by various hydrogel contact lens materials Invest Ophthalmol Vis Sci 2015;56: E-abstract 6109 [ PDF ]

Babaei Omali N, Subbaraman L, Heynen M, Thangavelu M, Dare E, Canavan K, Fadli Z, Jones L. Protein Deposition on Senofilcon A Contact Lenses in Symptomatic and Asymptomatic Lens Wearers Optom Vis Sci 2014;91: E-abstract 145186 [ PDF ]

Babaei Omali N, Subbaraman L, Schulze M, Heynen M, Canavan K, Fadli Z, Jones L. Clinical Signs, Symptoms, Tear Film and Meibum Composition in Asymptomatic Senofilcon A Contact Lens and Spectacle Wearers Optom Vis Sci 2014;91: E-abstract 145185 [ PDF ]

Back A, Chamberlain P, Logan N, Jones D, Gonzalez-Meijome J, Mei Saw S, Young G. Clinical evaluation of a dual-focus myopia control 1 day soft contact lens - 2-year results Optom Vis Sci 2016;93: E-abstract 160035

Bahoshy LP, Simpson TL, Situ P, Fonn D. In vivo contact lens drying reduces contrast sensitivity and increases measurement variability Optom Vis Sci 1998;75, 12s:169

Bai,Y., Ngo,W., Khanal,S., Nichols,K. K., Nichols,J. J. Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction Ocular Surface 2021;21(July):250-256 [ Show Abstract ]

Purpose: To evaluate the precorneal tear film (PCTF) and lipid layer (TFLL) thicknesses and thinning rates in meibomian gland dysfunction (MGD) using a combined ultra-high-resolution optical coherence tomography (OCT) and thickness dependent fringe (TDF) interferometry system.

Methods: Based on the Tear Film and Ocular Surface Society (TFOS) International Workshop on Meibomian Gland Dysfunction diagnostic algorithm, the Ocular Surface Disease Index (OSDI) and meibum grade score (MGS) were used to classify subjects into four groups: Normal (OSDI<13 and MGS<10), MGD (OSDI≥13 and MGS≥10), Asymptomatic MGD (OSDI<13 and MGS≥10), and Mixed (OSDI≥13 and MGS<10). The OCT/TDF system was used to capture PCTF and TFLL thicknesses and thinning rates. Kruskal-Wallis was used to compare median PCTF and TFLL thicknesses and thinning rates.

Results: There were 190 subjects categorized into four groups: Normal (n = 63), MGD (n = 51), Asymptomatic MGD (n = 29), and Mixed (n = 47). The PCTF was significantly thinner in the Mixed group (3.3 [1.2]) than in the Normal (p < 0.001), MGD (p < 0.001) and Asymptomatic MGD (p = 0.009) groups. Relative to the Normal (4.5 [4.5] μm/min) and Mixed (5.0 [2.0] μm/min) groups, the rate of PCTF thinning was faster in the MGD (8.1 [3.0] μm/min, both p < 0.001) and Asymptomatic MGD (6.9 [3.1] μm/min, p = 0.009 and p = 0.04, respectively) groups. The correlation between PCTF thinning rate and TFLL thickness was ρ = −0.46, p < 0.001.

Conclusions: Symptomatic and asymptomatic MGD shows rapid PCTF thinning rates (evaporation), while the PCTF thickness was reduced in mixed disease. Thicker lipid layers were associated with slower PCTF thinning.