New technology: A more realistic model eye

grad studentsWhile Chau-Minh Phan and Hendrik Walther were not the first to try to come up with a better in vitro system to test contact lens deposition and drug delivery, their tenacious approach in developing various iterations of the OcuFlow has produced a remarkable, patented device capable of simulating key aspects of the natural blink.

When it’s not practical to measure contact lens performance in vivo, what is the best way to simulate the ocular environment? While we can extrapolate results to predict in vivo lens performance, conventional in vitro methods are limited by conditions too far removed from the human eye.

While Chau-Minh Phan and Hendrik Walther were not the first to try to come up with a better in vitro system to test contact lens deposition and drug delivery, their tenacious approach in developing various iterations of the OcuFlow has produced a remarkable, patented device capable of simulating key aspects of the natural blink.

In addition to incorporating a range of motion representative of the lid’s vertical “blink” movement, the device is also able to take into consideration the intermittent air exposure that occurs between blinks and the potential to tailor and mimic fluid volume and flow of the natural tear film. Additionally, adjustable amounts of test solutions (i.e. artificial tears, protein and lipid solutions) can be released separately via separate sources, flow-through solution can be collected for in vitro analysis, and blink rate and extent of mechanical rubbing can be programmed.

See the video below and learn more about the OcuFlow here.

 

Waterloo study finds kids’ eyesight worsening earlier and largely uncorrected

Nearsightedness in children increases nearly fivefold from Grade 1 to Grade 8, with almost a third of the cases going undiagnosed and uncorrected, according to new research.

The team from the University of Waterloo’s Faculty of Science and the CNIB found that near-sightedness, or myopia, increases from 6 per cent to 28.9 per cent over the age range studied. Children from the Waterloo Region and Waterloo Catholic District School Boards participated in the landmark study and overall, 17.5 per cent of them are near-sighted.

Historically, myopia started at age 12 or 13, but now it is showing up more often in kids six or seven years old,” said Dr. Mike Yang, lead investigator and clinical scientist with the Centre for Ocular Research & Education (CORE) at Waterloo. “Our eyesight as a population is deteriorating and at a much younger age.

What surprised researchers the most was the number of cases of myopia going undetected and uncorrected. Left untreated, the condition worsens until the age of 21. Since it starts earlier in children today, it is possible that they may experience a much greater decline in their eyesight over a lifetime compared with previous generations.

Kids don’t know they can’t see the blackboard,” said Deborah Jones, co-lead investigator on the study and a clinical professor at the School of Optometry and Vision Science at Waterloo. “This kind of gradual loss in eyesight easily goes unnoticed without regular eye exams.

According to the report, a child has more than double the risk of developing myopia if a parent has it. However, the study found that spending one additional hour per week outdoors significantly lowers the odds of children becoming near-sighted.

The researchers plan to extend the pilot study to populations nationwide, looking at eye health within different ethnicities and environmental settings.

“We expect to find the same results in children across the country,” said Keith Gordon, Vice-President Research, CNIB. “It’s important for children between the ages of six and 19 to get an eye exam every year, as recommended by the Canadian Association of Optometrists. However even with annual check-ups, parents need to ensure that their children spend less time in front of screens and more time outside, even if it’s just one extra hour a week.”

Lyndon Jones, professor in Waterloo’s School of Optometry and Vision Science and director of the Centre for Ocular Research & Education, was the principal investigator on the project. The project development team included Keith Gordon, PhD, vice-president research at the CNIB, as well as Desmond Fonn, professor emeritus at Waterloo, Jill Woods, clinical research manager, and Doerte Luensmann, PhD, clinical scientist at CORE.

CNIB is a registered charity, passionately providing community-based support, knowledge and a national voice to ensure Canadians who are blind or partially sighted have the confidence, skills and opportunities to fully participate in life. For more information, visit www.cnib.ca.

Lab Tour and Networking Session

Monday, October 24th,2016: 2-4pm – Lab Tour and Networking Session with the UW Centre for Ocular Research & Education (CORE) [Information and Registration]

There will be an introduction to the state-of-the-art laboratory facilities available at the centre and their capabilities of supporting:

  • Microbiology and Toxicology testing – bacterial adhesion and growth, biofilm testing, microbial identification, cytotoxicity testing, biocompatibility testing
  • Cell culture – cell identification/phenotype, immunohistochemistry,
  • Tissue analysis
  • Determination of inflammatory response in cells and biological fluids
  • Protein and lipid biochemistry and quantification – including colorimetric and fluorescent assays, UV-Vis, radiolabel methods, HPLC, MS
  • Biomaterial development, including drug delivery materials
  • Biomaterial characterization – microscopy techniques include SEM, TEM, AFM and confocal microscopy, spectroscopic techniques include XPS and FT-IR, measurement of contact angle, biomaterial wettability, water content, protein and lipid uptake, optical transmissibility

Speakers:

Congratulations!

Congratulations to Lyndon Jones on being awarded the Glenn A. Fry Lecture Award for 2014 by the American Optometric Foundation and the American Academy of Optometry. The award is given annually to a distinguished scientist or clinician scientist in recognition of the quality, significance, impact, and relevance to optometry of his or her current research contributions.

Congratulations!

Brad awardTo …

  • Brad Hall, for being awarded the Murchison Callender Young Investigator Award at the 8the Canadian Optometry Schools Research Conference.
  • Lyndon Jones, for being awarded the Dr. Donald R. Korb Award by the American Optometric Association’s Contact Lens and Cornea Section, in recognition of innovation and leadership in the field of contact lenses and anterior segment disease.
  • Jill Woods and William Ngo, for becoming new Fellows of the American Academy of Optometry.